Abstract
Chronic hepatitis B virus (HBV) infection affects about 400 million people worldwide. The development of nucleoside analogs that inhibit HBV polymerase provides an important approach for treating HBV infection. The approval of lamivudine, adefovir and entecavir represents a cornerstone of hepatitis B therapy. However, the challenges from the resistance and the off-therapy viral rebound are still unmet, and there is a need of developing new therapeutic agents. This review will discuss the structure-activity relationship of the most significant anti-HBV nucleoside analogs and the latest development in the field.
Keywords: Hepatitis B virus, hepatitis, nucleoside, nucleoside phosphonate, nucleotide, lamivudine, emtricitabine, entecavir, adefovir
Current Topics in Medicinal Chemistry
Title: Nucleoside Analogs as Anti-HBV Agents
Volume: 6 Issue: 9
Author(s): Xiao-Xiong Zhou and Eddy Littler
Affiliation:
Keywords: Hepatitis B virus, hepatitis, nucleoside, nucleoside phosphonate, nucleotide, lamivudine, emtricitabine, entecavir, adefovir
Abstract: Chronic hepatitis B virus (HBV) infection affects about 400 million people worldwide. The development of nucleoside analogs that inhibit HBV polymerase provides an important approach for treating HBV infection. The approval of lamivudine, adefovir and entecavir represents a cornerstone of hepatitis B therapy. However, the challenges from the resistance and the off-therapy viral rebound are still unmet, and there is a need of developing new therapeutic agents. This review will discuss the structure-activity relationship of the most significant anti-HBV nucleoside analogs and the latest development in the field.
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Cite this article as:
Zhou Xiao-Xiong and Littler Eddy, Nucleoside Analogs as Anti-HBV Agents, Current Topics in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/156802606777303667
DOI https://dx.doi.org/10.2174/156802606777303667 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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