N-Methyl-D-Aspartate Receptor (NMDA) Antagonists as Potential Pain Therapeutics

Author(s): Dean G. Brown, Johannes J. Krupp

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 8 , 2006

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Abstract:

NMDA receptors are known to be involved in nociceptive transmission and pain processing. Many structurally diverse NMDA antagonists have been reported to have activity in both animal models and clinical models of neuropathic pain. Untoward side effects such as ataxia and sedation have severely limited the clinical uses of this class of potential therapeutics. However, antagonists at the glycine-site, NR2B sites and weak-binding channel blockers have demonstrated an improved side effect profile in animal models of pain. These types of compounds may hold potential promise for future pain therapies. This review covers reported pain data surrounding representative examples of NMDA antagonists and provides a current assessment of potential clinical utility.

Keywords: Sensitization, Chronic neuropathic pain, nociceptive events, Non-Competitive NMDA Receptor Antagonists, glutamate-competitive antagonists, spermidine

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2006
Page: [749 - 770]
Pages: 22
DOI: 10.2174/156802606777057571
Price: $65

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