Tricyclic Quinoxalinediones, Aza-kynurenic Acids, and Indole-2- Carboxylic Acids as In Vivo Active NMDA-Glycine Antagonists

Author(s): Ryu Nagata, Seiji Katayama, Ken-ichi Ohtani, Hiroyasu Tanaka, Kozo Shimago

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 7 , 2006

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This review article describes the development of in vivo active antagonists for the glycine binding site of the NMethyl- D-Aspartate (NMDA) receptor. There were several difficulties in identifying a class of antagonists with in vivo efficacy and only a few compounds succeeded in emerging with activity in vivo. A series of tricyclic quinoxalinediones was highly potent glycine antagonists in vitro and the derivatives having a zwitterionic moiety including SM-18400 indeed showed in vivo activity. Similarly, tricyclic indole-2-carboxylic acids having a zwitterionic moiety such as SM- 31900 were also active in vivo. In fact, SM-18400 and SM-31900 exhibited efficacy in several animal stroke models using intravenous infusion protocols. The practical syntheses of SM-18400 and SM-31900 as well as the novel synthesis of moderately active glycine antagonists, tricyclic azakynurenic acids, were also developed.

Keywords: N-Methyl-D-Aspartate, NMDA-glycine antagonist, SM-18400, SM-31900, tricyclic quinoxalinedione, tricyclic indole-2-carboxylic acid

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Article Details

Year: 2006
Page: [733 - 745]
Pages: 13
DOI: 10.2174/156802606776894500
Price: $65

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