Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines

Author(s): Akikazu Sakudo, Takashi Onodera, Yoshikazu Suganuma, Takanori Kobayashi, Keiichi Saeki, Kazuyoshi Ikuta

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPC), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.

Keywords: Prion protein, PrP-knockout mice, PrP-deficient cells, apoptosis, oxidative stress

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Article Details

Year: 2006
Page: [589 - 601]
Pages: 13
DOI: 10.2174/138955706776876159
Price: $65

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