Novel Anti-Viral Therapy: Drugs that Block HIV Entry at Different Target Sites

Author(s): Sandra Siegert, Peter Schnierle, Barbara S. Schnierle

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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Drugs that block the entry of human immunodeficiency virus type 1 (HIV-1) into host cells abrogate the establishment of a productive infection and should ideally diminish the chances of HIV-1 developing resistance. This review will give an overview of the mechanism by which the envelope glycoprotein mediates HIV-1 entry and will summarize current drug developments.

Keywords: HIV, entry, inhibitor

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Article Details

Year: 2006
Page: [557 - 562]
Pages: 6
DOI: 10.2174/138955706776876267
Price: $65

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