Ether Lipids as Anticancer Agents: Focus on Non-Phosphorus Cationic Glycerolipids

Author(s): N. V. Plyavnik, A. A. Shtil, G. A. Serebrennikova

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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This review focuses on the synthesis and mechanisms of antitumor activity of cationic nonphosphorus analogs of edelfosine. The role of variable length and mode of conjugation of the spacer group, the types of cationic head, and the length of the substituent at C(2) atom of the glycerol backbone are discussed, providing the basis for rational design of lipophilic anticancer drugs, in particular, for elimination of multidrug resistant cells.

Keywords: Ether lipids, Non-phosphorus cationic glycerolipids, Anticancer drugs, Edelfosine (ET-18-OMe)

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Article Details

Year: 2006
Published on: 01 March, 2012
Page: [533 - 542]
Pages: 10
DOI: 10.2174/138955706776876221
Price: $65

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