Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors

Author(s): Takayoshi Suzuki, Naoki Miyata

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.

Keywords: Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent

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Article Details

Year: 2006
Page: [515 - 526]
Pages: 12
DOI: 10.2174/138955706776876186
Price: $65

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PDF: 12