Title: Rational Design of Non-Hydroxamate Histone Deacetylase Inhibitors
VOLUME: 6 ISSUE: 5
Author(s):Takayoshi Suzuki and Naoki Miyata
Affiliation:Graduate School ofPharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori,Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
Keywords:Histone deacetylase, inhibitor, hydroxamic acid, non-hydroxamate, zinc enzyme, rational drug design, anticancer agent
Abstract: While most inhibitors of histone deacetylases (HDACs) are hydroxamic acid derivatives, several nonhydroxamates have recently been developed as inhibitors and attracted quite a deal of attention. In this review, we present the rational design, inhibitory effect and antiproliferative activity of non-hydroxamate HDAC inhibitors.
