Regulatory T Cells in Cancer Biology: A Possible New Target for Biochemical Therapies

Author(s): Dominik Wolf, Holger Rumpold, Anna-Maria Wolf

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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CD4+CD25+ T cells are essential for maintenance of self-tolerance and therefore have been referred to as regulatory T cells (Treg). Experimental tumor models revealed that Treg are potent inhibitors of an anti-tumor immune response. Treg are expanded in human cancer. Currently, a variety of strategies for the induction of a specific anti-tumor immune response are tested in preclinical and clinical settings. Biochemical strategies modifying and/or depleting Treg in cancer patients for an enhancement of vaccine-based therapeutic concepts will be discussed in detail in this review.

Keywords: Biochemical modification, regulatory T cell, immune evasion, cancer

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Article Details

Year: 2006
Page: [509 - 513]
Pages: 5
DOI: 10.2174/138955706776876230
Price: $65

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