Antioxidative Actions of Statins: Potential Mechanisms for Antiathersclerotic Effects

Author(s): Takanori Watanabe, Kenichi Yasunari, Munehoro Nakamura

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 5 , 2006

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Inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (statins) are widely used for the prevention of atherosclerotic diseases. The effects of statins on the generation of reactive oxygen species (ROS) by in vitro and in vivo were studied. Administration of statins significantly decreased ROS generation in vitro and in vivo.

Keywords: Statins, oxidative stress, atherosclerosis, carotid artery, leukocytes, flow cytemetory

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Article Details

Year: 2006
Page: [505 - 508]
Pages: 4
DOI: 10.2174/138955706776876249
Price: $65

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