Functional Chemokine Receptors in Allergic Diseases: Is CCR8 a Novel Therapeutic Target?

Author(s): E. Mitsuyama, Y. Kunori, T. Kamimura, O. Kaminuma

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 4 , 2006


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Abstract:

CC chemokine receptor (CCR) 8, which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. This review represents an overview of the functional roles of CCR8 in the pathogenesis of eosinophilic inflammation and debates the potential of recently developed CCR8 antagonists to treat allergic disorders.

Keywords: Allergy, atopic dermatitis, bronchial asthma, chemokine, eosinophil, knockout mouse, Th2 cell

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2006
Page: [463 - 466]
Pages: 4
DOI: 10.2174/138955706776361394
Price: $65

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