Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Author(s): Jie Zhang, Wenfang Xu

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 4 , 2006


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Abstract:

Neuraminidase (NA) is the major surface glycoprotein of the influenza virus. It has been considered a suitable target for designing agents against influenza viruses. Rational drug design of NA inhibitors is now in the clinic and is effective for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review a series of neuraminidase inhibitors and the recent progress in this field.

Keywords: Influenza, influenza virus, neuraminidase (NA), neuraminidase inhibitors (NAIs), sialic acid (SA), anti-influenza agents, antiviral, advances

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Article Details

VOLUME: 6
ISSUE: 4
Year: 2006
Page: [429 - 448]
Pages: 20
DOI: 10.2174/138955706776361475
Price: $65

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