Inhibitors and Modulators of β- and γ-Secretase

Author(s): Boris Schmidt, Stefanie Baumann, Hannes A. Braun, Gregor Larbig

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 4 , 2006

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Most gene mutations associated with Alzheimers disease point to the metabolism of amyloid precursor protein as potential cause. The β- and γ-secretases are two executioners of amyloid precursor protein processing resulting in amyloid β. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for γ-secretase. Several peptidic and non-peptidic leads were identified and first drug candidates are in clinical trials. This review focuses on the developments since 2003.

Keywords: Alzheimer's disease, secretase, aspartic protease, inhibitor, presenilin

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Article Details

Year: 2006
Page: [377 - 392]
Pages: 16
DOI: 10.2174/156802606776287027
Price: $65

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