Selective Androgen Receptor Modulators in Drug Discovery: Medicinal Chemistry and Therapeutic Potential

Author(s): Rodolfo Cadilla, Philip Turnbull

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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Modulation of the androgen receptor has the potential to be an effective treatment for hypogonadism, andropause, and associated conditions such as sarcopenia, osteoporosis, benign prostatic hyperplasia, and sexual dysfunction. Side effects associated with classical anabolic steroid treatments have driven the quest for drugs that demonstrate improved therapeutic profiles. Novel, non-steroidal compounds that show tissue selective activity and improved pharmacokinetic properties have been developed. This review provides an overview of current advances in the development of selective androgen receptor modulators (SARMs).

Keywords: SARMs, AR, modulation, tissue selectivity, testosterone, dihydrotestosterone, estradiol, hypogonadism

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Article Details

Year: 2006
Page: [245 - 270]
Pages: 26
DOI: 10.2174/156802606776173456
Price: $65

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