Effects of the Natural Isoflavonoid Genistein on Growth, Signaling Pathways and Gene Expression of Matrix Macromolecules by Breast Cancer Cells

Author(s): O. C. Kousidou, G. N. Tzanakakis, N. K. Karamanos

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

Become EABM
Become Reviewer
Call for Editor


Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17- estradiol and exerts antiestrogenic effects. It also affects the signal transduction components Akt, FAK, ErbB-2 and Bcl-2. Key enzymes implicated in cancer invasion are also affected by genistein. A critical evaluation of the effects of genistein on breast cancer growth, signaling and gene expression is presented in this review.

Keywords: genistein, estrogens, estrogen receptor, signaling, breast cancer

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [331 - 337]
Pages: 7
DOI: 10.2174/138955706776073420
Price: $65

Article Metrics

PDF: 2