Title: Cardiovascular Disease in Diabetes
VOLUME: 6 ISSUE: 3
Author(s):Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Katsuhiko Takenaka, Yuko Jinnouchi and Tsutomu Imaizumi
Affiliation:Department of InternalMedicine III, Kurume University School of Medicine, Kurume 830-0011,Japan.
Keywords:AGEs, atherosclerosis, diabetes, oxidative stress, renin-angiotensin system
Abstract: Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia, advanced glycation end products (AGEs) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.
