Unusual Amino Acids: Synthesis and Introduction into Naturally Occurring Peptides and Biologically Active Analogues

Author(s): G. Cardillo, L. Gentilucci, A. Tolomelli

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 3 , 2006

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This review covers our recent advances in the synthesis of unusual amino acids in optically pure form, and their introduction into naturally occurring peptides with specific biological properties, or into modified bioactive peptides, aiming to obtain analogues displaying enhanced performances in term of activity, bioavailability and resistance to enzymatic hydrolysis.

Keywords: Unusual amino acids, peptides, peptidomimetics, aziridines, α-substituted-β-amino acids, β-substituted-?-amino acids, endomorphin, lysobactin

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Article Details

Year: 2006
Page: [293 - 304]
Pages: 12
DOI: 10.2174/138955706776073394
Price: $65

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PDF: 19