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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Interactions of Chemicals and Metal Ions with Proteins and Role for Immune Responses

Author(s): Stefan F. Martin, Irmgard Merfort and Hermann-Josef Thierse

Volume 6, Issue 3, 2006

Page: [247 - 255] Pages: 9

DOI: 10.2174/138955706776073493

Price: $65

Abstract

Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.

Keywords: Allergic contact dermatitis, skin sensitization, chemical, metalion, hapten, arnica, nickel, proteomics

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