Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Title: Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Volume: 3 Issue: 3

Author(s): Ahmed Kamal, B. A. Kumar, M. Arifuddin and Sunanda G. Dastidar

Affiliation:

Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity

Abstract: Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.

Cite this article as:

Kamal Ahmed, Kumar A. B., Arifuddin M. and Dastidar G. Sunanda, Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin, Letters in Drug Design & Discovery 2006; 3 (3) . https://dx.doi.org/10.2174/157018006776286907