Synthesis and Biological Activity of New 4β-N-Heteroaryl Analogues of Podophyllotoxin

Author(s): Ahmed Kamal, B. A. Kumar, M. Arifuddin, Sunanda G. Dastidar

Journal Name: Letters in Drug Design & Discovery

Volume 3 , Issue 3 , 2006

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Some new 4β-N-heteroaryl analogues of podophyllotoxin have been prepared by employing Red Phosphorous/I2 reagent system. These 4β-N-heteroaryl analogues have been evaluated for their cytotoxicity against six human cancer cell lines and some representative ones have shown promising anticancer activity.

Keywords: Epipodophyllotoxin, benzothiazoles, pyrimidines, anticancer activity

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Article Details

Year: 2006
Published on: 01 March, 2012
Page: [205 - 209]
Pages: 5
DOI: 10.2174/157018006776286907
Price: $65

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