Influence of Human B-Casomorphin-7 on Specific Binding of 3H-Spiperone to the 5-HT2-Receptors of Rat Brain Frontal Cortex

Author(s): Oleg Y. Sokolov, Natalya V. Kost, Yurii A. Zolotarev, Ekaterina N. Ryukert, Andrey A. Zozulya

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 2 , 2006

Become EABM
Become Reviewer
Call for Editor


Using radio-receptor analysis, it has been demonstrated that human ε-casomorphin-7 (Tyr-Pro-Phe-Val- Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human β-casomorphin-7 was 8 μM. These data suggest that one of the mechanisms of neurotropic action of β-casomorphin-7 is might be associated with its influence on the serotoninergic system.

Keywords: Human β-Casomorphin-7, 5-HT2-receptors, spiperone

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [169 - 170]
Pages: 2
DOI: 10.2174/092986606775101733
Price: $65

Article Metrics

PDF: 3