Synthesis, Characterization and Biological Activity of Chemically Modified Insulin Derivative with Alpha Lipoic Acid

Author(s): Tao Huang, Kaixun Huang

Journal Name: Protein & Peptide Letters

Volume 13 , Issue 2 , 2006

Become EABM
Become Reviewer
Call for Editor


A novel chemically-modified insulin, ε-NB29-lipoyl insulin, was selectively prepared by the covalent linkage of α-lipoic acid (LA) to the ε-amino group of LysB29 of insulin without any protecting agent and analyzed by PAGE, HPLC, MALDI-TOF-MS. Monolipoyl- insulin maintained the glucose-lowering effect as well as native insulin and showed A longer duration of action than native insulin and an inhibitory effect towards trypsin degradation.

Keywords: Insulin, α-lipoic acid, chemical modification, lipoyl-insulin, monolipoyl-insulin

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Published on: 01 March, 2012
Page: [135 - 142]
Pages: 8
DOI: 10.2174/092986606775101599
Price: $65

Article Metrics

PDF: 5