Biological Activity of Cytokines: An Evolutionary Perspective

Author(s): G. Scapigliati, F. Buonocore, M. Mazzini

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 24 , 2006

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It appears evident that teleost fish are at present the vertebrate group in which, excluding mammals, most information on the immune system is available. However, despite the great impetus on the discovery of genes homologous to mammalian immunomodulatory molecules, the knowledge on biological activities exerted by cytokines is meager. This review reports the present knowledge on the biological activities of cytokine-like and cytokines in invertebrates and coldblooded vertebrates.

Keywords: Cytokine, Bioactivity, Evolution, Fish immunology, Teleost, IL-1

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Article Details

Year: 2006
Page: [3071 - 3081]
Pages: 11
DOI: 10.2174/138161206777947489
Price: $65

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