Hematopoietic Cell Formation in Leech Wound Healing

Author(s): A. Grimaldi, G. Tettamanti, G. Perletti, R. Valvassori, M. de Eguileor

Journal Name: Current Pharmaceutical Design

Volume 12 , Issue 24 , 2006

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The angiogenic process in vertebrates and hirudineans has been compared. The leech Hirudo medicinalis, subjected to an angiogenic stimulus (surgical explant or cytokine treatment) responds, as a vertebrate, with the formation of an extensive network of new vessels accompanied by the production of circulating cells. The reviewed data confirm the surprising similarity between hirudinean and vertebrate processes in wound healing, and suggest that basic common events such as antigenic expressions of endothelial and hemopoietic cells, cytokine secretion and regulation as well as extracellular matrix interactions, are conserved and extended across diverse species, tissues and developmental phases.

Keywords: Angiogenesis, hematopoietic cells, leeches, cytokines

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Article Details

Year: 2006
Page: [3033 - 3041]
Pages: 9
DOI: 10.2174/138161206777947443
Price: $65

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