Abstract
The role of individual fatty acids in blood pressure regulation is unclear, although it is known that the modifications in the levels of fatty acids in the diet are able to change the entire profile of fatty acids as well as cholesterol levels in cellular membranes. These chemical changes are accompanied by changes in the physiological state of the cellular membranes and have suggested an influence on cellular metabolism and of course, on the regulatory processes. Local and circulating renin-angiotensin-systems (RAS) are examples of systems that may be involved in the pathogenesis of hypertension. Angiotensin II (AngII) has been considered as the main effector peptide of the RAS, but other peptides derived from the metabolism of AngII, as angiotensin III (AngIII) and angiotensin IV (AngIV) have shown to play significant roles. This review will briefly summarize what is known about the effects of fatty acids, cholesterol and other related compounds on the activity of the aminopeptidases involved in the metabolism of Ang II and AngIII. We conclude that these enzyme activities may be modified in different way, and therefore, possible modifications in RAS and in cardiovascular illness may be possible too.
Keywords: Renin-angiotensin system, hypertension, aminopeptidase A, aminopeptidase B, aminopeptidase N, fatty acids, cholesterol, dietary manipulation
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Dietary Fat and Hypertension: A Novel Approach Through the Proteolytic Regulatory Enzymes of the Renin-Angiotensin-System
Volume: 4 Issue: 3
Author(s): J. M. Martinez-Martos and M. J. Ramirez-Exposito
Affiliation:
Keywords: Renin-angiotensin system, hypertension, aminopeptidase A, aminopeptidase B, aminopeptidase N, fatty acids, cholesterol, dietary manipulation
Abstract: The role of individual fatty acids in blood pressure regulation is unclear, although it is known that the modifications in the levels of fatty acids in the diet are able to change the entire profile of fatty acids as well as cholesterol levels in cellular membranes. These chemical changes are accompanied by changes in the physiological state of the cellular membranes and have suggested an influence on cellular metabolism and of course, on the regulatory processes. Local and circulating renin-angiotensin-systems (RAS) are examples of systems that may be involved in the pathogenesis of hypertension. Angiotensin II (AngII) has been considered as the main effector peptide of the RAS, but other peptides derived from the metabolism of AngII, as angiotensin III (AngIII) and angiotensin IV (AngIV) have shown to play significant roles. This review will briefly summarize what is known about the effects of fatty acids, cholesterol and other related compounds on the activity of the aminopeptidases involved in the metabolism of Ang II and AngIII. We conclude that these enzyme activities may be modified in different way, and therefore, possible modifications in RAS and in cardiovascular illness may be possible too.
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Martinez-Martos M. J. and Ramirez-Exposito J. M., Dietary Fat and Hypertension: A Novel Approach Through the Proteolytic Regulatory Enzymes of the Renin-Angiotensin-System, Cardiovascular & Hematological Agents in Medicinal Chemistry 2006; 4 (3) . https://dx.doi.org/10.2174/187152506777698308
DOI https://dx.doi.org/10.2174/187152506777698308 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
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