Abstract
Strategies that employ HSV amplicon vectors in the prevention and/or amelioration of pathogenic states afflicting the central nervous system (CNS) have been extensively documented in preclinical disease models. The versatility of the HSV amplicon platform allows for the implementation of therapeutic approaches that require expression of genes exhibiting neuroprotective or neuroplastic activities, or even applications that necessitate the elaboration of antigenspecific immune responses to pathogenic proteins/structures harbored within the CNS. This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders.
Keywords: Neuroprotection, Ischemic Injuries, Creutzfeld-Jacob disease (CJD), Prion Vaccination, Alzheimer, ’, s Disease, CNS inflammation
Current Gene Therapy
Title: HSV Amplicons: Neuro Applications
Volume: 6 Issue: 3
Author(s): Carolyn M. Tyler, Charles A. Wuertzer, William J. Bowers and Howard J. Federoff
Affiliation:
Keywords: Neuroprotection, Ischemic Injuries, Creutzfeld-Jacob disease (CJD), Prion Vaccination, Alzheimer, ’, s Disease, CNS inflammation
Abstract: Strategies that employ HSV amplicon vectors in the prevention and/or amelioration of pathogenic states afflicting the central nervous system (CNS) have been extensively documented in preclinical disease models. The versatility of the HSV amplicon platform allows for the implementation of therapeutic approaches that require expression of genes exhibiting neuroprotective or neuroplastic activities, or even applications that necessitate the elaboration of antigenspecific immune responses to pathogenic proteins/structures harbored within the CNS. This discourse highlights the successes and challenges encountered using HSV amplicon vectors as tools for the dissection of neural network function and as therapeutics directed against a variety of neurologic disorders.
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Cite this article as:
Tyler M. Carolyn, Wuertzer A. Charles, Bowers J. William and Federoff J. Howard, HSV Amplicons: Neuro Applications, Current Gene Therapy 2006; 6 (3) . https://dx.doi.org/10.2174/156652306777592045
DOI https://dx.doi.org/10.2174/156652306777592045 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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