Abstract
Pulmonary emphysema, a major component of chronic obstructive pulmonary diseases, is a highly prevalent progressive tissue-destructive disease, with no effective treatments. The interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible progression of the disease. Recent investigations have underlined the importance of the lung vasculature in the pathobiology of chronic obstructive pulmonary diseases offering new therapeutic strategies. This review will focus on the pulmonary microvessels as a target in the treatment of pulmonary emphysema.
Keywords: Emphysema, Vasculature, Apoptosis, Oxidative Stress, VEGF
Current Drug Targets
Title: The Vasculature as a Target in the Treatment of Pulmonary Emphysema
Volume: 7 Issue: 6
Author(s): H. A. Golpon and N. F. Voelkel
Affiliation:
Keywords: Emphysema, Vasculature, Apoptosis, Oxidative Stress, VEGF
Abstract: Pulmonary emphysema, a major component of chronic obstructive pulmonary diseases, is a highly prevalent progressive tissue-destructive disease, with no effective treatments. The interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible progression of the disease. Recent investigations have underlined the importance of the lung vasculature in the pathobiology of chronic obstructive pulmonary diseases offering new therapeutic strategies. This review will focus on the pulmonary microvessels as a target in the treatment of pulmonary emphysema.
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Cite this article as:
Golpon A. H. and Voelkel F. N., The Vasculature as a Target in the Treatment of Pulmonary Emphysema, Current Drug Targets 2006; 7 (6) . https://dx.doi.org/10.2174/138945006777435335
DOI https://dx.doi.org/10.2174/138945006777435335 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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