Growth Hormone Secretagogues

Author(s): Maria L. Isidro, Fernando Cordido

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 9 , Issue 3 , 2006


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Abstract:

Growth hormone secretagogues (GHSs) are synthetic molecules that stimulate and amplify pulsatile pituitary growth hormone release, via a separate pathway distinct from GH releasing hormone/somatostatin. The activity of GHSs is not fully specific for GH secretion; some GHSs also have slight releasing activity on other pituitary hormones and mediate GH independent biological activities. The first GHSs were discovered in 1977. Since then, an intensive research to synthesize a potent oral GHSs has been undertaken. Although the potential applications of GHSs are numerous, long term trials are needed to evaluate the clinical efficacy and safety of these substances. In the present article we review the historic background of GHSs, their potential clinical uses, the types and the main GHSs that have been synthesized hitherto.

Keywords: Growth hormone secretagogues, growth hormone releasing peptides, growth hormone, ghrelin

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Article Details

VOLUME: 9
ISSUE: 3
Year: 2006
Published on: 01 March, 2012
Page: [175 - 180]
Pages: 6
DOI: 10.2174/138620706776055458
Price: $65

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