Abstract
This paper reviews the principal strategies for multicomponent determinations of pharmaceutical products and related compounds using flow-injection analysis (FIA). The relevancy of this topic in the pharmaceutical field and close areas such as clinical, food and biochemical analysis is pointed out. As an alternative to chromatographic and electrophoretic methods, multicomponent FIA is specially suitable for a rapid quantification of analytes and processing large sets of samples. The achievement of selective measurement conditions to carry out the quantification of each drug without interferences is commonly needed in multicomponent analysis. The main approaches for gaining selectivity are based on specific reagents, multi-way or fast-scanning detectors, serial and parallel multi-channel manifolds. Alternatively, chemometric methods for data analysis can be used when selectivity is not fully accomplished.
Keywords: Flow-injection analysis, Multicomponent analysis, Multichannel manifolds, Chemometrics, Active drugs
Current Pharmaceutical Analysis
Title: Multicomponent Determination of Drugs Using Flow-Injection Analysis
Volume: 2 Issue: 2
Author(s): Leah Hlabangana, Santiago Hernandez-Cassou and Javier Saurina
Affiliation:
Keywords: Flow-injection analysis, Multicomponent analysis, Multichannel manifolds, Chemometrics, Active drugs
Abstract: This paper reviews the principal strategies for multicomponent determinations of pharmaceutical products and related compounds using flow-injection analysis (FIA). The relevancy of this topic in the pharmaceutical field and close areas such as clinical, food and biochemical analysis is pointed out. As an alternative to chromatographic and electrophoretic methods, multicomponent FIA is specially suitable for a rapid quantification of analytes and processing large sets of samples. The achievement of selective measurement conditions to carry out the quantification of each drug without interferences is commonly needed in multicomponent analysis. The main approaches for gaining selectivity are based on specific reagents, multi-way or fast-scanning detectors, serial and parallel multi-channel manifolds. Alternatively, chemometric methods for data analysis can be used when selectivity is not fully accomplished.
Export Options
About this article
Cite this article as:
Hlabangana Leah, Hernandez-Cassou Santiago and Saurina Javier, Multicomponent Determination of Drugs Using Flow-Injection Analysis, Current Pharmaceutical Analysis 2006; 2 (2) . https://dx.doi.org/10.2174/157341206776819283
DOI https://dx.doi.org/10.2174/157341206776819283 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer
Current Pharmaceutical Design Therapeutic Options for the Management of Aromatase Inhibitor- Associated Bone Loss
Endocrine, Metabolic & Immune Disorders - Drug Targets Current Therapeutic Advances in Patients and Experimental Models of Huntington's Disease
Current Drug Targets Cannabinoid Hyperemesis Syndrome
Current Drug Abuse Reviews Molecular Mechanisms in Aging and Current Strategies to Counteract Sarcopenia
Current Aging Science Schistosoma mansoni Antigens as Modulators of the Allergic Inflammatory Response in Asthma
Endocrine, Metabolic & Immune Disorders - Drug Targets Biosurfactants as a Novel Additive in Pharmaceutical Formulations: Current Trends and Future Implications
Current Drug Metabolism 11β-Hydroxysteroid Dehydrogenase Type 1: A Potential Therapeutic Target for the Control of Local Glucocorticoid Concentrations
Current Enzyme Inhibition Obesity: Pathophysiology and Clinical Management
Current Medicinal Chemistry The Concept of Phenoptosis and its Usefulness for Controlling Aging
Current Aging Science Pharmacogenomics of Oral Antithrombotic Drugs
Current Pharmaceutical Design Glycosphingolipid Clusters as Organizers of Plasma Membrane Rafts and Caveolae
Current Organic Chemistry Circulating Nucleic Acids in Plasma and Serum: Roles in Diagnosis and Prognosis in Diabetes and Cancer
Infectious Disorders - Drug Targets Pulmonary Neuroendocrine Cell System in Health and Disease
Current Respiratory Medicine Reviews FoxO3a Governs Early Microglial Proliferation and Employs Mitochondrial Depolarization with Caspase 3, 8, and 9 Cleavage During Oxidant Induced Apoptosis
Current Neurovascular Research Enzymatic Processing of <i>Omega</i> 3 Long Chain Polyunsaturated Fatty Acid Oils
Current Nutrition & Food Science Gastroesophageal Reflux Disease (GERD): Current Agents and Future Perspective
Current Pharmaceutical Design Insulin Resistance, Inflammation and Atherosclerosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Applicability of mTOR Inhibition in Solid Tumors
Current Cancer Drug Targets Targeting the Phosphatidylinositol 3-Kinase/AKT Pathway for the Treatment of Multiple Myeloma
Current Medicinal Chemistry