Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2

Author(s): Victoria Magrioti, George Kokotos

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 5 , Issue 2 , 2006

Become EABM
Become Reviewer
Call for Editor


PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.

Keywords: Analgesic, anti-inflammatory agents, inflammation, inhibitors, 2-oxoamide, pain, phospholipase A2, trifluoromethyl ketone

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Published on: 01 March, 2012
Page: [189 - 203]
Pages: 15
DOI: 10.2174/187152306776872451
Price: $65

Article Metrics

PDF: 6