Abstract
Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Current Medicinal Chemistry
Title: Application of Radioisotopes in Inflammation
Volume: 13 Issue: 8
Author(s): A. R. Jalilian, M. Bineshmarvasti and S. Sardari
Affiliation:
Keywords: Inflammation, radiopharmaceuticals, diagnosis, therapy, SPECT, PET, NSAID, FUO
Abstract: Since the discovery of artificially produced radioisotopes in the 1930s, an estimated 10-12 million nuclear medicine diagnostic and therapeutic procedures are currently performed each year only in the United States. Gamma emission imaging has been successfully applied to almost every organ of the body (brain, bone, heart, kidney, lung, neuroreceptors) as well as sites of inflammation, atherosclerosis, and thrombosis. FDG-PET has been used in some of the inflammatory diseases as well. On the other hand, both alpha and beta-emitting isotopes have been evaluated for brachytherapy of rheumatoid diseases, each with different radiobiological effectiveness. The current status of radionuclides for imaging, therapy and research studies of inflammatory processes is reviewed here and a look into the future directions is described at the conclusion.
Export Options
About this article
Cite this article as:
Jalilian R. A., Bineshmarvasti M. and Sardari S., Application of Radioisotopes in Inflammation, Current Medicinal Chemistry 2006; 13 (8) . https://dx.doi.org/10.2174/092986706776361049
DOI https://dx.doi.org/10.2174/092986706776361049 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis
Anti-Cancer Agents in Medicinal Chemistry Ciclesonide: A Closer Look at its Systemic and Oropharyngeal Safety Profile
Current Drug Safety Angiotensin-Converting Enzyme Inhibitors: Mechanisms of Action and Implications In Anesthesia Practice
Current Pharmaceutical Design Descriptive Analysis of Mortality Predictors in H1n1 Influenza in South Indian Patients
Infectious Disorders - Drug Targets Moving Troponin Testing into the 21st Century: Will Greater Sensitivity Be Met with Greater Sensibility?
Cardiovascular & Hematological Disorders-Drug Targets The Pathobiology of Endothelin-1 in Vein Graft Disease: Are ETA Receptor Antagonists the Solution to Prevent Vein Graft Failure?
Current Vascular Pharmacology Extracellular Matrix Remodeling in Hypertension
Current Hypertension Reviews Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases
Current Medicinal Chemistry The Prothrombotic State in Hypertension and the Effects of Antihypertensive Treatment
Current Pharmaceutical Design COVID-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods
Anti-Cancer Agents in Medicinal Chemistry Cigarette Smoke-Induced Proteostasis Imbalance in Obstructive Lung Diseases
Current Molecular Medicine Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications
Current Pharmaceutical Design Origin and Biological Significance of Shed-Membrane Microparticles
Endocrine, Metabolic & Immune Disorders - Drug Targets Preface
Combinatorial Chemistry & High Throughput Screening An insight into the Interaction between Clopidogrel and Proton Pump Inhibitors
Current Drug Metabolism Evaluation of the Pulmonary Veins and Left Atrial Volume using Multidetector Computed Tomography in Patients Undergoing Catheter Ablation for Atrial Fibrillation
Current Cardiology Reviews Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry Efficacy and Safety of Mesenchymal Stromal Cells Therapy for COVID-19 Infection: A Systematic Review and Meta-analysis
Current Stem Cell Research & Therapy From Amino Acids to Proteins as Targets for Metal-based Drugs
Current Drug Metabolism Toxicities of Targeted Agents in Advanced Renal Cell Carcinoma
Current Clinical Pharmacology