Antiangiogenesis Drug Design: Multiple Pathways Targeting Tumor Vasculature

Title: Antiangiogenesis Drug Design: Multiple Pathways Targeting Tumor Vasculature

Volume: 13 Issue: 8

Author(s): Haizhen Zhong and J. P. Bowen

Affiliation:

Keywords: VEGF isoforms, chemotherapy, Curcumin, MMP-9 deficient mice, antimitotic agents, COX-2

Abstract: The initiation, growth, and development of new blood vessels through angiogenesis are essential for tumor growth. Tumor masses require access to blood vessels for a sufficient supply of oxygen and nutrients to maintain growth and metastasis. Inhibiting tumor blood vessel formation as proposed by Judah Folkman in the early 1970s, therefore, offers promising therapeutic approaches for treating tumor afflicted patients. The blood vessel growth in normal tissues is regulated though a delicate and complex balance between the collective action of proangiogenic factors (e.g., vascular endothelial growth factor, VEGF) and the collective action of angiogenic inhibitors (e.g., thrombospondin-1). In pathological angiogenesis, the angiogenic switch is shifted toward the proangiogenic factors, and if the imbalance continues, irregular tumor vessel growth is the result. Despite intense research, the mechanism of the angiogenic switch is not fully understood. Many factors, however, have been shown to be involved in regulating the equilibrium between angiogenic stimulants and inhibitors. VEGFR tyrosine kinase, methionine aminopeptidase-2 (MetAP-2), p53, tubulin, cyclooxygenase-2 (COX-2), and matrix metalloproteinases (MMPs) all directly and/or indirectly influence the angiogenic switch. This review will describe some of the advances in inhibitor design and the mechanisms of action for the aforementioned factors (targets) involved in angiogenesis regulation. Our discussion reveals that a diaryl group separated by various connecting modules is one of the most common features for antiangiogenesis drug design. This idea has been a working pharmacophore hypothesis for our own antiangiogenic drug design endeavors over the years. The recent advances of combination therapy (angiogenesis inhibitors with other chemotherapy/radiation) are also discussed.

Cite this article as:

Zhong Haizhen and Bowen P. J., Antiangiogenesis Drug Design: Multiple Pathways Targeting Tumor Vasculature, Current Medicinal Chemistry 2006; 13 (8) . https://dx.doi.org/10.2174/092986706776361085