Abstract
Because of the number of distinguishable interactions within the DNA major groove, there is considerable interest in discovering the governing factors involved in DNA recognition. Carbohydrates represent a class of DNAinteractive agents capable of binding the major groove due to their size and intricate distribution of hydrophobic and hydrophilic interactions within their molecular structure. To date a limited number of carbohydrates have been found to interact within the DNA major groove; the majority have been shown to bind within the minor groove. Representative carbohydrates that bind within the major groove include neocarzinostatin, nogalamycin, and a few aminoglycoside (neomycin) conjugates developed in our labs. An overview of the various DNA groove-binding carbohydrates is presented, with particular emphasis on novel aminoglycoside-based approaches in probing the molecular environment and requirements therein associated with the DNA major groove.
Keywords: DNA groove-binding carbohydrates, Enediyne antibiotics, Anthracyclines, anticancer agents, Mithramycin
Current Organic Chemistry
Title: Major Groove Recognition of DNA by Carbohydrates
Volume: 10 Issue: 6
Author(s): Bert Willis and Dev P. Arya
Affiliation:
Keywords: DNA groove-binding carbohydrates, Enediyne antibiotics, Anthracyclines, anticancer agents, Mithramycin
Abstract: Because of the number of distinguishable interactions within the DNA major groove, there is considerable interest in discovering the governing factors involved in DNA recognition. Carbohydrates represent a class of DNAinteractive agents capable of binding the major groove due to their size and intricate distribution of hydrophobic and hydrophilic interactions within their molecular structure. To date a limited number of carbohydrates have been found to interact within the DNA major groove; the majority have been shown to bind within the minor groove. Representative carbohydrates that bind within the major groove include neocarzinostatin, nogalamycin, and a few aminoglycoside (neomycin) conjugates developed in our labs. An overview of the various DNA groove-binding carbohydrates is presented, with particular emphasis on novel aminoglycoside-based approaches in probing the molecular environment and requirements therein associated with the DNA major groove.
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Cite this article as:
Willis Bert and Arya P. Dev, Major Groove Recognition of DNA by Carbohydrates, Current Organic Chemistry 2006; 10 (6) . https://dx.doi.org/10.2174/138527206776359739
DOI https://dx.doi.org/10.2174/138527206776359739 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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