Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics

Author(s): Gabriele Zybarth, Nikolai Kley

Journal Name: Current Drug Targets

Volume 7 , Issue 4 , 2006

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Abstract:

The genomics and proteomics sciences have fundamentally changed the ways in which drug targets are being identified, characterized and validated. Here we review how genomics and proteomics research is improving our understanding of genetic determinants of drug susceptibility and response and, conversely, how organic small molecules mediate their pharmacological effects by modulating genome and proteome activities. We also examine the effect this improved understanding has on the drug discovery and development process.

Keywords: Genomics, proteomics, pharmacogenetics, pharmacogenomics, chemical proteomics, drug resistance, activitybased protein profiling, yeast three-hybrid

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2006
Page: [387 - 395]
Pages: 9
DOI: 10.2174/138945006776359430
Price: $65

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