A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, an Update

Author(s): W. Waelput, P. Brouckaert, D. Broekaert, J. Tavernier

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 4 , 2006

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Abstract:

Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptins biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.

Keywords: leptin receptor, CRH-knockout, lymphocytes, DTH reaction, pro-inflammatory mediators, Septic Shock

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Article Details

VOLUME: 13
ISSUE: 4
Year: 2006
Page: [465 - 475]
Pages: 11
DOI: 10.2174/092986706775527929
Price: $65

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