Clinical Aspects of Natural Anti-Angiogenic Drugs

Author(s): C. P. Neal, D. P. Berry, H. Doucas, M. M. Manson, W. Steward, G. Garcea

Journal Name: Current Drug Targets

Volume 7 , Issue 3 , 2006

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Abstract:

Natural products represent a rich resource for drug discovery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived from varied species of plant, animal and micro-organism. Over a dozen of these agents have now entered clinical trial. This review discusses evidence for the efficacy of this drug class and key issues in the translation of pre-clinical results into the development of efficacious drugs for clinical use.

Keywords: Angiogenesis, cancer, therapeutics, proliferation, natural, endogenous

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2006
Page: [371 - 383]
Pages: 13
DOI: 10.2174/138945006776054951
Price: $65

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