Antimitotic Agents of Natural Origin

Author(s): Advait Nagle, Wooyoung Hur, Nathanael S. Gray

Journal Name: Current Drug Targets

Volume 7 , Issue 3 , 2006

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Antimitotic agents have been the most successful pharmacological agents for the treatment of cancer. The term "antimitotic agent" has traditionally been synonymous with tubulin-targeting compounds, but as a consequence of the large number of new compounds and mechanisms that have been identified recently, a much broader definition is currently needed. This review attempts to provide a broad overview of compounds and their cognate protein targets which result in a block in mitosis. Focus has been placed on agents that act directly on the mitotic machinery rather than on targets further upstream such as growth factor receptors.

Keywords: Microtubules, Paclitaxel, Epothilone A, malignant glioma cell lines, tubulin interacting agents, Vinca Alkaloids

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Article Details

Year: 2006
Page: [305 - 326]
Pages: 22
DOI: 10.2174/138945006776054933
Price: $65

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