5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents

Author(s): Josef Jampilek, Martin Dolezal, Veronika Opletalova, Jiri Hartl

Journal Name: Current Medicinal Chemistry

Volume 13 , Issue 2 , 2006

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Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

Keywords: 5-lipoxygenase, FLAP, LTA4-hydrolase, leukotrienes, antileukotrienic agents

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Article Details

Year: 2006
Page: [117 - 129]
Pages: 13
DOI: 10.2174/092986706775197935
Price: $65

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