Invasive Pulmonary Aspergillosis in Acute Leukemia: Current Issues for Pathogenesis, Diagnosis and Treatment

Author(s): Ridvan Ali, Tulay Ozcelik

Journal Name: Current Respiratory Medicine Reviews

Volume 2 , Issue 1 , 2006

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Invasive pulmonary aspergillosis (IPA) is a frequently life-threatening fungal infection that complicates acute leukemia patients following conventional chemotherapy and bone marrow transplantation. The mortality rate reaches 50% in leukemic patients during chemotherapy-induced neutropenia and can exceed 90% in bone marrow transplantation patients. Despite advances in antimicrobial therapy and supportive care, IPA remains a major clinical problem in patients with acute leukemia. Current issues for IPA in adults are reviewed.

Keywords: Invasive pulmonary aspergillosis (IPA), acute leukemia

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Article Details

Year: 2006
Page: [3 - 13]
Pages: 11
DOI: 10.2174/157339806775486191

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PDF: 14