Recent Progress in Application of Spectroscopic Methods for Assigning Absolute Configuration of Optically Active Sulfoxides

Author(s): Maria I. Donnoli, Stefano Superchi, Carlo Rosini

Journal Name: Mini-Reviews in Organic Chemistry

Volume 3 , Issue 1 , 2006

Become EABM
Become Reviewer
Call for Editor


In the recent years, in addition to the more traditional methods based on X-ray diffraction and mechanistic considerations, the problem of the configurational assignment of optically active sulfoxides has been approached with spectroscopic methods. In this review the methods based on the use of NMR spectroscopy and electronic circular dichroism are described, as well as the emerging approaches based on the analysis of vibrational CD spectra, on the ab initio calculation of the optical rotation and on the cholesteric induction in nematic solvents. The advantage and limitations of each approach are discussed with a major attention to their reliability and practicality.

Keywords: Absolute configuration, sulfoxides, CD, optical rotatory power, NMR, VCD

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [77 - 92]
Pages: 16
DOI: 10.2174/157019306775474149

Article Metrics

PDF: 17