Immunological Mechanisms of Specific Allergen Immunotherapy

Author(s): Carsten B. Schmidt-Weber, Kurt Blaser

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
Formerly Current Drug Targets - Inflammation & Allergy

Volume 5 , Issue 1 , 2006


Allergy is an immunological disorder, which is driven by uncontrolled allergen-activated T cell subsets, leading to immediate type hypersensitivity against otherwise harmless environmental allergens. These allergens are tolerated by healthy individuals as well as by patients, who successfully underwent allergen-specific immunotherapy (SIT). The successful SIT is characterized by the induction of T cell unresponsiveness against the given allergen. Regulatory T cells (Tregs), which are installed or enhanced by SIT and govern the activity of potentially pro-allergic effector T cells, mediate this unresponsiveness. The current article reviews the mechanisms underlying the balance of these cell populations along with suppressive mechanisms of SIT, which may serve as future drug targets.

Keywords: inflammatory factors, allergy, antigen-presenting cells, pathogen-associated molecular patterns (PAMPs), phosphatidylinositol, , 3-phosphatase (PI3K)

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [15 - 21]
Pages: 7
DOI: 10.2174/187152806775269321

Article Metrics

PDF: 19