Straightforward Three-Component Palladium-Catalysed Synthesis of Pyridazin-3(2H)-one Libraries

Author(s): Alberto Coelho, Eddy Sotelo

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 9 , Issue 1 , 2006


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Abstract:

A simple and straightforward three-component methodology for the solution phase high-throughput synthesis of 2,5-disubstituted pyridazin-3(2H)-one libraries has been developed. The diversity at position 5 of the heterocycle is determined by the use of Suzuki, Sonogashira, Heck or Stille coupling.

Keywords: Multicomponent reactions, pyridazinones, palladium, combinatorial chemistry

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2006
Published on: 01 March, 2012
Page: [15 - 19]
Pages: 5
DOI: 10.2174/138620706775213868

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