Understanding Apoptosis in Terms of QSAR

Author(s): Rajeshwar P. Verma

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 6 , Issue 1 , 2006

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Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.

Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)

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Article Details

Year: 2006
Page: [41 - 52]
Pages: 12
DOI: 10.2174/187152006774755528

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