Protein Misfolding Disorders: A Trip into the ER

Indexed in: Scopus, EBSCO.

Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a ...
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Autophagy and the Ubiquitin-Proteasome System - Protein Catabolism Comes Full Circle

Pp. 136-147 (12)

Natalia B. Nedelsky and J. Paul Taylor


All cells are endowed with two catabolic pathways for degrading protein: the ubiquitinproteasome system (UPS) and autophagy. While these routes of protein degradation were long considered to be parallel and complementary systems, new evidence has revealed interaction between the UPS and autophagy, suggesting a coordinated relationship that becomes critical in times of cellular stress. Here we introduce the basics and parallels of the UPS and autophagy, review the evidence for cross-regulation of the two systems, and highlight their emerging coordinated relationship. Throughout, we review the evidence suggesting that impairment of autophagy could contribute to the initiation or progression of age-related neurodegeneration.


Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38120 USA.