Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design

Author(s): Zhengming Guo, Suryanarayana Vangapandu, Robert William Sindelar, Larry Anthony Walker and Robert David Sindelar

Pp: 285-308 (24)

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Abstract

Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.

Keywords: Quassinoids, semi-synthesis, total synthesis, biological activities, SAR, antileukemic and antimalarial activities

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