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Volume: 4
Editor(s): Atta-ur-Rahman, Allen B. Reitz and M. Iqbal Choudhary
DOI: 10.2174/97816080520731090401 eISBN: 978-1-60805-207-3, 2009 ISBN: 978-1-60805-346-9 ISSN: 1567-2042 (Print) ISSN: 1875-5763 (Online)
Indexed in: Scopus, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.
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“Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in Medicinal Chemistry” covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. “Frontiers in Medicinal Chemistry” aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.
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Preface promotion: free to download
Pp. iv-v (2)
Allen B. Reitz, M. Iqbal Choudhary and Atta-ur-Rahman
Contributors promotion: free to download
Pp. ix-xiii (5)
Methods for Ligand-Based Virtual Screening Open Access Plus
Pp. 1-22 (22)
Jurgen Bajorath
Simple Coumarins: Privileged Scaffolds in Medicinal Chemistry
Pp. 23-85 (63)
Maria F.M. Borges, Fernanda M.F. Roleira, Nuno J.S.P. Milhazes, Eugenio U. Villare and Lourdes S. Penin
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Chromatography and Computational Chemical Analysis for Drug Discovery
Pp. 86-129 (44)
Toshihiko Hanai
New Therapeutic and Experimental Aspects of Chelators as Antidotes of Metal Toxicity
Pp. 130-182 (53)
Veda M. Varnai, Maja Blanusa, Martina Piasek and Krista Kostial
Taurine Analogues: A New Class of Therapeutics
Pp. 183-213 (31)
Ramesh Chandra Gupta, Thida Win and Shmuel Bittner
Digitalis-Like Compounds: The Discovery of the O-Aminoalkyloxime Group as a Very Powerful Substitute for the Unsaturated γ -Butyrolactone Moiety
Pp. 214-236 (23)
Mauro Gobbini and Alberto Cerri
Combinatorial Natural Products: From Cloning to Analysis
Pp. 237-247 (11)
Paul Budworth, Julia Khandurina and Andras Guttman
Medicinal Plants for the Prevention and Treatment of Bacterial Infections
Pp. 248-284 (37)
Gail B. Mahady
Biologically Active Quassinoids and Their Chemistry: Potential Leads for Drug Design
Pp. 285-308 (24)
Zhengming Guo, Suryanarayana Vangapandu, Robert W. Sindelar, Larry A. Walker and Robert D. Sindelar
Medicinal Plant Extracts and Molecules as the Source of New Anti-Snake Venom Drugs
Pp. 309-346 (38)
Andreimar M. Soares, Silvana Marcussi, Renata S. Fernandes, Danilo L. Menaldo, Tassia R. Costa, Miriam V. Lourenco, Ana Helena Januario and Paulo S. Pereira
Recent Advances in the Development of Selective Small Molecule Inhibitors for Cyclin-Dependent Kinases
Pp. 347-370 (24)
Hiroshi Hirai, Nobuhiko Kawanishi and Yoshikazu Iwasawa
Protein Tyrosine Phosphatases and Their Inhibitors
Pp. 371-423 (53)
Yogesh S. Tingare, Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li
Matrix Metalloproteinase Inhibitors: A Review on Pharmacophore Mapping and (Q)SARs Results
Pp. 424-462 (39)
Christos A. Kontogiorgis, Paraskevi Papaioannou and Dimitra J. Hadjipavlou-Litina
Drug Delivery Strategies for the Treatment of Helicobacter pylori Infections
Pp. 463-490 (28)
Barbara R. Conway
Anti-HIV Activities of Natural Antioxidant Caffeic Acid Derivatives: Toward an Antiviral Supplementation Diet
Pp. 491-505 (15)
Fabrice Bailly and Philippe Cotelle
Recent Advances in New Structural Classes of Anti-Tuberculosis Agents
Pp. 506-540 (35)
Amit Nayyar, Sanjay R. Patel and Rahul Jain
Applications for Peptide-Based Cancer Vaccine Design
Pp. 541-561 (21)
Eliada Lazoura, Stephanie L. Day and Vasso Apostolopoulos
Telomerase Inhibition and Cancer: Might Platinum Based Drugs Have a Future as Anti-Telomerase Pharmacological Approach?
Pp. 562-586 (25)
Donato Colangelo and Domenico Osella
Recent Developments in the Field of Non Peptidic α vβ 3 Antagonists
Pp. 587-618 (32)
Barbara Cacciari, Pamela Crepaldi, Stephanie Federico and Giampiero Spalluto
Non-Hydroxamate Histone Deacetylase Inhibitors
Pp. 619-641 (23)
Takayoshi Suzuki and Naoki Miyata
New Lipid-Lowering Agents Acting on LDL Receptors
Pp. 642-660 (19)
Hubert Scharnagl, Tatjana Stojakovic and Winfried Marz
Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes
Pp. 661-687 (27)
John W. Huffman and Lea W. Padgett
Novel Therapies for Asthma - Advances and Problem
Pp. 688-706 (19)
Garry M. Walsh
Drugs to Treat Inflammation: A Historical Overview
Pp. 707-729 (23)
Michael Whitehouse
Drug Development and Diagnostics for Alzheimer's Disease Up to 2008
Pp. 730-766 (37)
Nicole Hottecke, Stefanie Baumann, Ali Taghavi, Hannes A. Braun and Boris Schmidt
Therapeutic Opportunities in Alzheimer Disease: Current Concepts
Pp. 767-788 (22)
Michael W. Marlatt, Paula I. Moreira, Hyoung-Gon Lee, Gemma Casadesus, Rudy J. Castellani, Atsushi Takeda, Akihiko Nunomura, Xiongwei Zhu, George Perry and Mark A. Smith
N-Hydroxyurea and Acyl Nitroso Compounds as Nitroxyl (HNO) and Nitric Oxide (NO) Donors
Pp. 789-804 (16)
S. Bruce King
New Anticonvulsant Agents
Pp. 805-841 (37)
Barbara Malawska
Selective Neuronal Nitric Oxide Synthase Inhibitors Open Access Plus
Pp. 842-882 (41)
Haitao Ji, Erik P. Erdal, Elizabeth A. Litzinger, Jiwon Seo, Yaoqiu Zhu, Fengtian Xue, Jianguo Fang, Jinwen Huang and Richard B. Silverman
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