Frontiers in Medicinal Chemistry

Volume: 3

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry ...
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New Trends in the Design of Drugs Against Alzheimer's Disease

Pp. 249-284 (36)

Pierre Francotte, Pascal de Tullio, Pierre Fraikin and Bernard Pirotte


First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a growing health problem.

AD is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors, based on the cholinergic hypothesis (1976).

During the past decade, advances in neurobiology have conducted to the identification of new targets. Although some of these innovative approaches tend to delay onset of AD, others are still symptomatic.

In this review, we present an overview of the several strategies and new classes of compounds against AD.


Natural and Synthetic Drugs Research Center, Dept of Medicinal Chemistry, University of Liege, Av. de l’Hopital, 1, B36, 4000 Liege, Belgium.