NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers
Pp. 184-213 (30)
Hoang Nam Nhat,
Tran Thi Hong
We present a concise review on current advances in the field of application of Nuclear
Magnetic Resonance (NMR) in Structure-Activity Relationship (SAR) study of nanostructure
drugs, particularly of paclitaxel-loaded nanocarriers. A short introduction of NMR to nonspecialists
is also included. The review is separated into two parts, the first discusses in broader
context the concepts and potentials of drug-loaded nanocarriers as the modern tumour active
targeting systems and the second focuses on the paclitaxel-loaded nanocarriers, especially on
conformations and tubulin-binding forms of paclitaxel. The application of nanoscience in
pharmaceutical researches explodes very fast with many anti-tumour drugs recently been approved
to the market. We survey only the important and latest issues in this field.
NMR, paclitaxel, nanocarrier, drug delivery, structure, cancer.