Structure-Activity Relationship Studies in Drug Development by NMR Spectroscopy

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Drug discovery is still a process which involves screening of a large number of chemical compounds against a defined biological target. However, this approach is now being gradually replaced by more ...
[view complete introduction]

US $

*(Excluding Mailing and Handling)

NMR Studies in Nanoparticle Drug Delivery Systems: Paclitaxel Loaded Nanocarriers

Pp. 184-213 (30)

DOI: 10.2174/978160805164911101010184

Author(s): Hoang Nam Nhat, Tran Thi Hong


We present a concise review on current advances in the field of application of Nuclear Magnetic Resonance (NMR) in Structure-Activity Relationship (SAR) study of nanostructure drugs, particularly of paclitaxel-loaded nanocarriers. A short introduction of NMR to nonspecialists is also included. The review is separated into two parts, the first discusses in broader context the concepts and potentials of drug-loaded nanocarriers as the modern tumour active targeting systems and the second focuses on the paclitaxel-loaded nanocarriers, especially on conformations and tubulin-binding forms of paclitaxel. The application of nanoscience in pharmaceutical researches explodes very fast with many anti-tumour drugs recently been approved to the market. We survey only the important and latest issues in this field.


NMR, paclitaxel, nanocarrier, drug delivery, structure, cancer.