Frontiers in Medicinal Chemistry

Volume: 1

Indexed in: Scopus, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Medicinal Chemistry is a book series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. Frontiers in Medicinal Chemistry ...
[view complete introduction]

US $

*(Excluding Mailing and Handling)

Strategies to Improve Stability and Bioavailability of Peptide Drugs

Pp. 513-528 (16)

Céline Adessi and Claudio Soto


Peptides play a major role in a diversity of biological functions, such as hormones, growth factors and neuropeptides. However, the development of peptides as therapeutic drugs has been limited by their poor metabolic stability and their inability to readily cross membrane barriers such as the intestinal and blood-brain barriers. The aim of peptide medicinal chemistry is to develop strategies to overcome these problems. Recent progress in chemical synthesis and design have resulted in several strategies for producing modified peptides and mimetics with lower susceptibility to proteolysis and improved bioavailability, which has increased the probability of obtaining useful drugs structurally related to parent peptides. This review describes different experimental approaches to transforming a peptide into a potential drug and provides examples of the usefulness of these strategies.


Hoffmann-La Roche Ltd., CNS Research, CH-4070 Basel, Switzerland