Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders

Indexed in: Scopus, EBSCO.

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. ...
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Pp. 57-70 (14)

Lawrence M. Agius


Integral constitutional events in neurofibrillary degeneration relate particularly to the multiphosphorylation sites that discretely segregate molecules in a loosely bound structure present intraneuronally. It is significant that neurofibrillary tangles correspond to spread of disease involvement in Alzheimer brains. It would further appear that the further progression of these lesions would significantly constitute a variable correlate of the senile plaque load.


University of Malta Medical School Mater Dei Hospital, Malta